Prof. Dr. Dr. habil. Alexander Prange

Hochschule Niederrhein. Your way.
Microbiology and Food Hygiene, Head of Competence Center Microbiology & Biotechnology (CCMB) Competence Centre for Applied Mycology and Environmental Studies (KAMU)

German

Microbiology and food hygiene" is concerned with the occurrence and behavior of microorganisms (bacteria, yeasts, molds, parasites and viruses) in food and feed along the production chain, from primary production to the consumer. This field is concerned with the detection and control of microorganisms in food. This is of great importance against the background of preventive consumer health protection and the production of microbiologically safe and high quality food.

Major issues in food microbiology and hygiene are therefore: contamination and microbial spoilage of food; food-borne infections and microbial intoxications; shelf life and fermentation of food; cleaning and disinfection; microbiological investigation of food; assessment and management of microbiological risks in food production; quality and hygiene management; development of detection methods for microorganisms;

 

Core research areas:

  • Microbial interactions of molds and bacteria in relation to the formation of mycotoxins.
  • "Air borne molds and bacteria" - air and industrial hygiene
  • X-ray absorption spectroscopy in the near-edge range (XANES spectroscopy) in applied (micro)biology: agricultural, food and environmental systems
  • Sulfur and selenium in (micro-)biological systems: e.g. chemical/toxic effects of sulfur on molds and plants; uptake and metabolism of sulfur in bacteria and fungi


Cooperation partner:

  • Center for Advanced Microstructures and Devices (CAMD), Louisiana State University, Baton Rouge, LA, USA.
  • Dept. of Geology and Geophysics, Louisiana State University, Baton Rouge, LA, USA
  • Synchrotron Radiation Group, University of Bonn, Germany
  • Sulfur Working Group, Institute of Microbiology & Biotechnology, University of Bonn, Germany
  • Canadian Light Source (CLS) University of Sasketchewan, Saskatoon, Canada


The research is sponsored by The Hochschule Niederrhein (internal project funding), the German Research Foundation, the State of North Rhine-Westphalia (MIWFT), the National Science Foundation (NSF, USA) the Heinrich Hertz Foundation and companies in the food industry.

English

Research

Microbiology and Food Hygiene deals with the occurrence and the behavior of microorganisms (bacteria, yeasts, moulds, parasites and viruses) in food and feed products from the primary agricultural production to the consumer. This discipline is concerned with the detection and the control of microorganisms in food products. This is especially important when regarding the protective, consumer protection and the production of microbiologically safe and high-quality food products.

Main topics of Food Microbiology and Hygiene are: contamination and microbial spoilage of food products; food borne infections and intoxications; food preservation and fermentation; cleaning and disinfection; microbiological investigations of food products; assessment and management of microbiological risks in food production; Quality and hygiene management; Development of detection methods for microorganisms;

Main research topics:

  • Microbial interactions of moulds and bacteria in relation to mycotoxin production
  • Air borne moulds and bacteria
  • Application of X-ray absorption near edge spectroscopy (XANES) in Applied (Micro-) biology: Agricultural, food and environmental systems
  • Sulfur and selenium in (micro-)biological systems: Chemical/toxic influence on moulds and plants; Uptake and metabolism of sulfur in bacteria and fungi


Collaboration partners:

  • Center for Advanced Microstructures and Devices (CAMD), Louisiana State University, Baton Rouge, LA, USA
  • Dept. of Geology and Geophysics, Louisiana State University, Baton Rouge, LA, USA
  • Synchrotron radiation group, Bonn University
  • Microbial Sulfur group, Institute for Microbiology & Biotechnology, Bonn University
  • Canadian Light Source (CLS) University of Sasketchewan, Saskatoon, Canada


Research is supported by grants of the Niederrhein University of Applied Sciences (internal project funding), the German Research Foundation (DFG), the state North Rhine- Westphalia (MIWFT), the National Science Foundation (NSF, USA), the Heinrich-Hertz-Foundation and the private companies of food industry.

Industry cooperation/technology transfer

  • Microbiological testing of food e.g. meat, drinking water, cereals for human pathogenic and toxinogenic microorganisms (e.g. Enterobacteriaceae, Salmonella, Staphylococcus aureus, Listeria monocytogenes, Bacillus cereus etc.) and spoilage agents (e.g. lactic acid bacteria, molds, yeasts)
  • Quality assurance and industrial consulting Consulting of food producers and processors for the introduction to HACCP concepts and IFS, for industrial hygiene and for all food microbiological problems, also on-site in the company
  • Training and practical continuing training of employees in the field of microbiology and hygiene on site or in small groups in the laboratories of the Hochschule Niederrhein
  • Working on special practical problems in the laboratories of The Hochschule Niederrhein or directly in the company (e.g. in the context of internship semesters or R&D projects). Through the possible support of prospective Diplom-Oecotrophologists, Bachelor of Science - and Master of Science- graduates, competent additional employees are available on request to carry out customer-specific research and development work.

competence centre

Publications

Textbook

Krämer, J. & Prange, A. (2023). Food microbiology. 8th edition, UTB 1421 paperback, Eugen Ulmer Verlag, Stuttgart, 420 pp.

Krämer, J. & Prange, A. (2017). Food microbiology. 7th edition, UTB 1421 paperback, Eugen Ulmer Verlag, Stuttgart, 400 pp.

 

Journal articles (peer-reviewed)

54 Szlachetko, J., Szade, J., Beyer, E., Błachucki, W., Ciochoń, P., Dumas, P., Freindl, K., Gazdowicz, G., Glatt, S., Guła, K., Hormes, J., Indyka, P., Klonecka, A., Kołodziej, J.,Kołodziej, T., Korecki, J., Korecki, P., Kosiorowski, F., Kosowska, K., Kowalski, G., Kozak, M., Kozioł, P., Kwiatek, W., Liberda, D., Lichtenberg, H., Madej, E., Mandziak, A., Marendziak, A., Matlak, K., Maximenko, A., Nita, P., Olszowska, H., Panaś, R., Partyka-Jankowska, E., Piszak, M., Prange, A., Rawski, M., Roman, M., Rosmus, M., Sikora, M., Sławek, J., Sobol, T., Sowa, K., Spiridis, N., Stępień, J., Szczepanik, M., Ślęzak, T., Tyliszczak, T., Ważny, G., Wiechecki, J., Wilgocka-Ślęzak, D., Wolanin, B., Wróbel, P., Wróbel, T., Zając, M., Wawrzyniak, A. & Stankiewicz, M. (2023). SOLARIS National Synchrotron Radiation Centre in Krakow, Poland. The European Journal of Physics Plus 138, 1-10., https://doi.org/10.1140/epjp/s13360-022-03592-9, (open access publication).

53. Thume, M., Lange, J., Unkel, M., Prange, A. & Schürmeyer, M. (2022). Blockchain-based traceability in the food industry: requirements analysis along the food supply chain. International Journal of Sustainable Agricultural Management and Informatics 8, 219-241.

52. Hormes, J., Klysubun, W., Göttert, J., Lichtenberg, H., Maximenko, A., Morris, K., Nita, P., Prange, A., Szade, J., Wagner, L. & Zajac, M. (2021). A new SOLARIS beamline optimized for X-ray spectroscopy in the tender energy range. Nuclear Inst. and Methods in Physics Research B 489, 76-81.

51 Schlösser, I. & Prange, A. (2019). Effects of selected natural preservatives on the mycelial growth and ochratoxin A production of the food-related moulds Aspergillus westerdijkiae and Penicillium verrucosum. Food Additives and Contaminants Part A 36, 1411-1418.

50. Schlösser, I. & Prange, A.* (2019).Antifungal activity of selected natural preservatives against Aspergillus westerdijkiae and Penicillium verrucosum and the interactions of these preservatives with food components. Journal of Food Protection 82, 1751-1760.

49.Prange, A., Sari, M., Ameln von, S., Hajdu, C., Hambitzer, R., Ellinger, S. & Hormes, J. (2019). Characterization of selenium speciation in selenium-enriched button mushrooms(Agaricus bisporus) and selenized yeasts (dietary supplement) using X-ray absorption near-edge structure (XANES) spectroscopy. Journal of Trace Elements in Medicine and Biology 51, 164-168.

48. Ameln von, S., Dicks, L., Prange, A. & Ellinger, S. (2018).Dietary supplements made from mushrooms. An overview of health-related aspects with a focus on cardiometabolic effects and an overview on food law regulations. Ernaehrungsumschau-International 65, 92-99.

47 Schlösser, I. & Prange, A. (2018). Antifungal activity of selected natural preservatives on the foodborne molds Penicillium verrucosum and Aspergillus westerdijkiae. FEMS Microbiology Letters 365, 1-8. doi: 10.1093/femsle/fny125

46. Etter, D., Rupp, A., Prange, A. & Drissner, D. (2018).Inactivation of mould spores in a model system on raisins by low energy beam. Food Control 92, 357-361.

45. Zanzen, U., Bovenkamp-Langlois, G. L., Klysubun, W., Hormes, J. & Prange, A. (2018). The interaction of cooper ions with Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli - an X-ray absorption near edge structure (XANES) spectroscopy study. Archives of Microbiology 200, 401-412.

44. Sari, M., Prange, A., Lelley, J.I., & Hambitzer, R. (2017). Screening study of beta-glucan content in commercially cultivated and wild growing mushroom species. Food Chemistry 216, 45-51.

43.Chitpirom, K., Akaracharanya, A., Tanasupawat, S., Leepipatpiboon, N., Kim, K.-W., Hormes, J., & Prange, A. (2017). Characterization of arsenic speciation using XANES spectroscopy in Comamonas terrae, an arsenite-oxidizing bacterium isolated from agricultural soil in Thailand. Journal of Food, Agriculture and Environment 15, 44-47.

42. Grube, S., Schönling, J., & Prange, A. (2015).Development and evaluation of a triplex-real-time PCR system to detect the plant-pathogen molds Alternaria spp., Fusarium spp. and C. purpurea. Journal of Microbiological Methods 119, 180-188.

41 Grube, S., Schönling, J., & Prange, A. (2015). Comparison of different methods for the recovery of DNA from spores of mycotoxin producing moulds in spiked food samples. Letters in Applied Microbiology 60, 524-530.

40. Engel, A.S., Bovenkamp, G.L., Prange, A. & Hormes, J. (2014).In situ speciation of sulfur vapors by X-ray absorption near edge structure spectroscopy. Chemical Geology 380, 1-6.

39. Bovenkamp, G. L., Zanzen, U., Katla S. K., Hormes, J. & Prange, A. (2013).The interaction of silver ions with Staphylococcus aureus, Listeria monocytogenes, and Escherichia coli - an X-ray absorption near edge structure (XANES) spectroscopy study. Applied and Environmental Microbiology 79, 6385-6390.

38 Zanzen, U., Bovenkamp, G. L., Krishna, K. S., Hormes, J. & Prange, A. (2013). Antibacterial action of copper ions on food-contaminating bacteria. Acta Biologica Szegediensis 57, 149-151.

37. chitpirom, K., Akaracharanya, A., Tanasupawat, S., Leepipatpiboon, N., Kim, K.-W., Hormes, J., & Prange, A.* (2012). Characterization of arsenic speciation in Comamonas sp. A3-3, an arsenite-oxidizing bacterium isolated from agricultural soil in Thailand using XANES spectroscopy. Journal of General and Applied Microbiology 58, 245-251.

36. Bovenkamp, G. L., Zanzen, U., Katla S. K., Hormes, J. & Prange, A. (2013). The interaction of silver ions with Staphylococcus aureus, Listeria monocytogenes, and Escherichia coli - an X-ray absorption near edge structure (XANES) spectroscopy study. Applied and Environmental Microbiology 79, 6385-6390.

35. Bovenkamp, G. L., Prange, A., Schuhmacher, W., Ham, K., Smith, A. P. & Hormes, J. (2013).Lead uptake in diverse plant families: a study applying X-ray absorption near edge spectroscopy. Environmental Science and Technology 47, 4375-4382.

34. Chitpirom, K., Tanasupawat, S., Akaracharanya, A., Leepipatpiboon, N., Prange, A., Kim, K.-W., Lee, K. C. & Lee, J.-S. (2012).Comamonas terra sp. nov., an arsenite-oxidizing bacterium isolated from agricultural soil in Thailand. Journal of General and Applied Microbiology 58, 245-251.

33. Wang, J., Hitchcock, A. P., Karunakaran, C., Prange, A., Franz, B., Harkness, T., Liu, Y., Obst, M., & Hormes, J. .(2011).3D Chemical and elemental imaging by STXM spectro-tomogragphy. American Institute for Physics: Conference Proceedings 1365: 215-218. XRM2010.

32. Franz, B., Balkundi, S. S., Dahl, C., Lvov, Y. M. & Prange, A. (2010). Layer-by-layer nano-encapsulation of microbes: A new concept of controlled, modified architecture of cells surfaces and to investigate uptake of compounds, substrates and particles into cells. Macromolecular Biosciences 10, 164-172.

31 Franz, B., Gerke, T., Lichtenberg, H., Hormes, J., Dahl, C. & Prange, A. (2009). Unexpected extracellular sulfur species during growth of Allochromatium vinosum with reduced sulfur compounds. Microbiology 155, 2766-2774.

30. Franz, B., Lichtenberg, H., Hormes, J., Dahl, C. & Prange, A.* (2009). The speciation of soluble sulfur compounds in bacterial culture fluids by X-ray absorption near edge structure spectroscopy. Environmental Technology 30, 1281-1289.

29. Balkundi, S. S., Franz, B., Lvov, Y. M. & Prange, A. (2008). Polyelectrolyte nanoencapsulation of bacteria through LbL assembly. Polymer Materials Science and Engineering 99, 635-636.

28. Lee, Y.-J., Prange, A., Lichtenberg, H., Rohde, M., Dashti, M. & Wiegel, J. (2007). In situ speciation of sulfur globules produced from thiosulfate reduction by Thermoanaerobacter sulfurigignens. Journal of Bacteriology 189, 7525-7529.

27. Milles, J., Krämer, J. & Prange, A. (2007).Development of a proteomic approach to monitor protein expression in mycotoxin producing moulds. Mycotoxin Research 23, 161-165.

26 Milles, J., Krämer, J. & Prange, A. (2007). In vivo competitive interactions of Fusarium graminearum with Aspergillus ochraceus and Penicillium verrucosum in suboptimal stored wheat with regard to mycotoxin production. Journal of Food, Agriculture & Environment 5, 384-388.

25. Kizilkaya, O., Singh, V., Desta, Y., Pease, M., Roy, A., Scott, J., Goettert, J., Morikawa, E., Hormes, J. & Prange, A. (2007).The infrared microspectroscopy beamline at CAMD. American Institute of Physics Proceedings Series Journal 879, 1759-1762.

24. Kizilkaya, O., Prange, A., Steiner, U., Oerke, E.-C., Scott, J. D., Morikawa, E. & Hormes, J. (2007). The Infrared microspectroscopy beamline at CAMD and its application in plant-pathogen interactions. Nuclear Instruments and Methods in Physics Research A 582, 274-276.

23 Lee, Y.-J., Dashti, M., Prange, A., Rainey, F. A., Rohde, M., Whitman, W. B. & Wiegel, J. (2007). Thermoanaerobacter sulfurigignens sp. nov., a novel anaerobic thermophilic bacterium reducing 1 M thiosulfate to elemental sulfur and tolerating 90 mM sulfite. International Journal of Systematic and Evolutionary Microbiology 57, 1429-1434.

22. Franz, B., Modrow, H., Hormes, J. & Dahl, C. Prange, A. (2007).Elemental sulfur oxidation in the phototrophic purple sulfur bacterium Allochromatium vinosum. Microbiology 153, 1268-1274.

21 Engel, A. S., Lichtenberg, H., Prange, A. & Hormes, J. (2007).Speciation of sulfur from naturally-occurring, filamentous microbial mats from sulfidic cave springs using X-ray absorption near edge spectroscopy. FEMS Microbiology Letters 269, 54-62.

20. Saß, V., Milles, J., Krämer, J. & Prange, A. (2007).Competitive interactions of Fusarium graminearum and Alternaria alternata in vitro in relation to deoxynivalenol and zearalenone production. Journal of Food, Agriculture & Environment 5, 257-261.

19 Lichtenberg, H., Prange, A., Modrow, H. & Hormes, J. (2007). Characterization of sulfur compounds in coffee beans by sulfur K-XANES spectroscopy. American Institute of Physics Proceedings 882, 824-826.

18. Prange, A.*, Oerke, E.-C., Steiner, U., Bianchetti, C. M., Hormes, J. & Modrow, H. (2005).Spatially resolved sulfur K-edge XANES spectroscopy for the in situ-characterization of the fungus-plant interaction Puccinia triticina and wheat leaves. Journal of Phytopathology 153, 627-632.

17 Prange, A., Modrow, H., Hormes, J., Krämer, J. & Köhler, P. (2005). Influence of mycotoxin producing fungi(Fusarium, Aspergillus, Penicillium) on gluten proteins during suboptimal storage of wheat after harvest and competitive interactions between field and storage fungi. Journal of Agricultural and Food Chemistry 53, 6930-6938.

16. Prange, A., Birzele, B., Krämer, J., Meier, A., Modrow, H. & Köhler, P. (2005). Fusarium-inoculated wheat: Deoxynivalenol contents and baking quality in relation to infection time. Food Control 16, 739-745.

15. Saß, V., Milles, J., Krämer, J. & Prange, A. (2005).Simple and efficient cell disruption of extremely small quantities of mycelium of phytopathogenic mycotoxin-producing moulds for quantitative extraction of genomic DNA. Mycotoxin Research 21, 213-217.

14. Prange, A.*, Birzele, B., Hormes, J. & Modrow, H. (2005).Investigation of different human pathogenic and food contaminating bacteria and moulds grown on selenite/selenate and tellurite/tellurate by X-ray absorption spectroscopy. Food Control 16, 723-728.

13. Birzele, B. & Prange, A. (2004).Weeds in organic farming: Seeds of Galium aparine as possible source of inoculum for Fusarium infection and elevated mycotoxin content? Journal of Applied Botany and Food Quality 78, 164-168.

12 Prange, A., Engelhardt, H., Trüper, H. G. & Dahl, C. (2004). Towards the role of the sulfur globule proteins of Allochromatium vinosum: Interposon mutagenesis of the sulfur globule protein genes and expression studies by real-time RT-PCR. Archives of Microbiology 182, 165-174.

11. Prange, A.*, Birzele, B., Krämer, J., Chauvistré, R., Modrow, H., Hormes, J. & Köhler, P. (2003).Characterization of sulfur speciation in low molecular weight subunits of glutenin after reoxidation with potassium iodate and potassium bromate at different pH values using X-ray absorption near-edge structure (XANES) spectroscopy. Journal of Agricultural and Food Chemistry 51, 7431-7438.

10 Birzele, B. & Prange, A. (2003). Fusarium spp. and storage fungi in suboptimally stored wheat: mycotoxins and influence on wheat gluten proteins. Mycotoxin Research 19, 162-170.

9 Prange, A.* & Modrow, H. (2002). X-ray absorption spectroscopy and its application in biological, agricultural and environmental research. Re/Views in Environmental Science & Bio/Technology 1, 259-276.

8. Prange, A., Dahl, C., Trüper, H. G., Behnke, M., Hahn, J., Modrow, H. & Hormes, J. (2002). Investigation of SH-bonds in biologically important compounds by X-ray absorption spectroscopy. European Physical Journal D 20, 589-596.

7. Prange, A., Dahl, C., Trüper, H. G., Chauvistré, R., Modrow, H. & Hormes, J. (2002).X-ray absorption spectroscopy of bacterial sulfur globules: a detailed reply. Microbiology 148, 2268-2270.

6 Prange, A., Chauvistré, R., Modrow, H., Hormes J., Trüper, H. G. & Dahl, C. (2002). Quantitative speciation of sulfur in bacterial sulfur globules: X-ray absorption spectroscopy reveals at least three different species of sulfur. Microbiology 148, 267-276.

4 Antes, S., Birzele, B., Prange, A., Krämer, J., Meier, A., Dehne, H.-W. & Köhler, P. (2001). Rheological and breadmaking properties of wheat samples infected with Fusarium spp. Mycotoxin Research 17A, 76-80.

4 Prange, A., Kühlsen, N., Birzele, B., Arzberger, I., Hormes, J., Antes, S. & Köhler, P. (2001). Sulfur in wheat gluten: In situ analysis by X-ray absorption near edge structure (XANES) spectroscopy. European Food Research and Technology 212, 570-575.

3 Birzele, B., Prange, A., Schönling, J. & Krämer, J. (2000).Development of deoxynivalenol contents in relation to the PCR detection of potentially trichothecene producing Fusarium spp. during storage of wheat. Mycotoxin Research 16A, 46-49.

2 Birzele, B., Prange, A. & Krämer, J. (2000).Deoxynivalenol and ochratoxin A in German wheat and changes of level in relation to storage parameters. Food Additives and Contaminants 17, 1027-1035.

1 Prange, A., Arzberger, I., Engemann, C., Modrow, H., Schumann, O., Trüper, H. G., Steudel, R., Dahl, C. & Hormes, J. (1999). In situ analysis of sulfur in the sulfur globules of phototrophic sulfur bacteria by X-ray absorption near edge spectroscopy. Biochimica et Biophysica Acta 1428, 446-454.

 

Articles in textbooks / other journals

17 Lichtenberg, H., Elfenkemper, C., Mahltig, B., Prange, A., Hormes, J. & Klysubun, W. (2023). Synchrotron radiation for the analysis of inorganic fibers - especially basalt fibers. Melliand International 1/23, 29-31.

16. Ameln von, S., Messelhäußer, U. & Prange, A. (2023). A foodborne pathogen before the ECJ: application of food safety criteria for Listeria monocytogenes. ZLR- Journal of all food law, 1/2023, 129-137.

15 Ameln von, S., Holle, M. & Prange, A. (2021). Anticipated expert opinions in food law - legal requirements and practical relevance. Food and Law - LMuR 4/2021, 251-256.

14. Ameln von, S. & Prange, A. (2018).The new Swiss food law - an overview.DLR - Deutsche Lebensmittel-Rundschau - Analytik, Forschung, Prozesse, Recht 06/2018, 263-268.

13 Schlösser, I., Ameln von, S. & Prange, A.* (2018). Natural inhibitors - an alternative for chemical preservatives in the fight against mold? Rundschau für Fleischhygiene und Lebensmittelüberwachung 01/2018, 18-22.

12 Hilgenberg, B., Prange, A. & Vossebein, L. (2016). Testing and regulation of antimicrobial textiles. In: Antimicrobial Textiles. Elsevier Ltd, Woodhead Publishing Series in Textiles, 7-18.

11 Prange, A. & Zanzen, U. (2015). Microbiological-hygienic standards for community catering. In: Handbook of community catering, J. Wetterau, V. Peinelt & U. Fladung, 202-226.

10. Mandl, K., Schieck, J., Silhavy-Richter, K., Prange, A., Schneider, V., & Schmidt, H. (2015). Vines take up yeasts from soil and transport them through the vine to the stem and skins of grapes Ithaka Journal 2015, 349-355.

9. Prange, A. (2010/2014 updated). Molds in food, Praxishandbuch Behrs Verlag, loose-leaf collection, 21 pp.

8. Grube, S., Schönling, J., & Prange, A.* (2014). Molds in food - detection by DNA extraction and real-time PCR. DLR - Deutsche Lebensmittel-Rundschau - Analytik, Forschung, Prozesse, Recht 11/2014, 511-515.

7 Kindermann, M. & Prange, A. (2010). Hygiene aspects of preparation and temperature dependence of microorganism activity. Chapters 4.3, 4.4. in Food processing in the household, U. Gomm & W. Lichtenberg (eds.), aid Infodienst, Verbraucherschutz, Ernährung, Landwirtschaft e.V., Bonn, 109-115.

6 Prange, A., Hormes, J. & Modrow, H. (2008). X-ray absorption spectroscopy as a tool for the detection and identification of sulfur compounds in phototrophic organisms. In: Sulfur Metabolism in Phototrophic Organisms, R. Hell, C. Dahl, T. Leustek & D. Knaff, (Eds.) Series "Advances in Photosynthesis and Respiration", Springer, Berlin Heidelberg, 461-482.

5. Prange, A. (2008).Speciation analysis of microbiologically produced sulfur by X-ray absorption near edge structure (XANES) spectroscopy. In: Microbial Sulfur Metabolism, C. Friedrich & C. Dahl (Eds.), Springer, Berlin Heidelberg, 259-272.

4. Dahl, C. & Prange, A. (2006).Bacterial sulfur globules: Occurrence, structure and metabolism. In: Inclusions in Prokaryotes, chapter 2, J. M. Shively (Ed.). Series "Microbiology Monographs", Springer-Verlag, Berlin Heidelberg, 21-51.

3. Prange, A., Birzele, B., Modrow, H., Hormes, J. & Köhler, P. (2004).Analysis of sulphur speciation in gluten proteins by X-Ray Absorption Near Edge Structure (XANES) spectroscopy. In The Gluten Proteins, D. Lafiandra, S. Masci & R. D'Ovidio (Eds.), Royal Society of Chemistry (RSC), Cambridge, pp. 327-330. (ISBN 0-85404-633-X).

2. Birzele, B. & Prange, A. (2002). Wheat quality: mycotoxins, moulds and X-ray absorption near edge structure spectroscopy of gluten proteins. In Quality and Plant Breeding, ed. German Society for Quality Research DGQ e.V., Munich, 313-322. (ISBN 3-9805230-6-3).

1 Dahl, C., Prange, A. & Steudel, R. (2002). Metabolism of natural polymeric sulfur compounds. (Chapter 2) In: Biopolymers, Vol. 9. Miscellaneous Biopolymers and Biodegradation of Synthetic Polymers, A. Steinbüchel & S. Matsumura (Eds.), Wiley-VCH, Weinheim, 35-62. (ISBN 3-527-30228-X).

 

Promotions

PhDs in microbiology and food hygiene since 2015
(in cooperation with Witten/Herdecke University; Prof. Prange is Apl. Professor at the Department of Virology and Microbiology in Witten)

6 Sven Jöran Krämer, MD (2021).

"Campylobacter spp. in raw milk: differentiation of microbiologically culturable and non-culturable cells by PMA-PCR".

Speaker: Prof. Dr. rer. nat. Dr. agr. Dr. habil. Alexander Prange
Co-speaker: Prof. Dr. rer. nat. Anja Ehrhardt

5. Dr. rer. nat. Inga Schlösser (2020)

"Antifungal Effect of Selected Natural Preservatives on Food-Relevant and Mycotoxin-Producing Molds".

Speaker: Prof. Dr. rer. nat. Dr. agr. Dr. habil. Alexander Prange
Co-speaker: Prof. Dr. rer. nat. Anja Ehrhardt

4. dr. rer. medic. Susanne von Ameln (2019)

Food supplements in legal comparison of German, Swiss and US-American law and classification of the practical examples "medicinal and edible mushrooms" and "selenium-enriched mushrooms"

Speaker: Prof. Dr. rer. nat. Dr. agr. Dr. habil. Alexander Prange
Correferent: Prof. Dr. iur. Martin Holle

3. dr. rer. medic. Ulrike Zanzen (2018)

"X-ray absorption spectroscopic and microbiological studies on the effect of copper ions on selected human pathogenic bacteria."

Speaker: prof. dr. rer. nat. dr. agr. Dr. habil. Alexander Prange
Co-speaker: Prof. Dr. rer. nat. Johannes Krämer

2nd Dr. rer. medic. Miriam Sari (2017)

"Biofunctional ingredients (beta-glucans) in medicinal and edible mushrooms".

Speaker: Prof. Dr. rer. nat. Dr. agr. Dr. habil. Alexander Prange
Co-speaker: Prof. Dr. troph. habil. Reinhard Hambitzer

1st Dr. rer. nat. Sabrina Grube (2015).

"Development of a multiplex real-time PCR detection system for simultaneous detection of food-relevant mold genera".

Speaker: Prof. Dr. rer. nat. Dr. agr. Dr. habil. Alexander Prange
Co-speaker: Prof. Dr. rer. nat. Anja Ehrhardt

theses

Requests for supervision of bachelor's, and master's theses in the field of "Microbiology, Food Hygiene, Quality Assurance/Management" please personally after the courses or in the Consultation hours.

Diploma /Bachelor's /Master's theses

76. Carolin Ertel: "Relevance of allergen purification in the production of the Zentis company from a legal and analytical point of view when using soy and nut protein" (November 2022).

75. Helena Losberg: "Inactivation of pathogenic bacteria and mold spores using moist and dry heat: process validation using the example of a meat matrix." (March 2021)

74th Viola Mestemacher: "Fresh Cut Fruits - Optimization of the washing process for a reduction of microbiological contamination." (July 2019)

73 Annalena Rupp: "Experimental investigation on the enzymatic extraction of prebiotic galactooligosaccharides from whey" (May 2019).

72. Isabel Jung: "Comparative investigations on two fruit juice bottling lines of Valensina GmbH and their packaging materials" (March 2018)

71. Sandra Schoemackers: "Effect of the volatile phase of selected natural inhibitors in vitro and in situ on food-relevant molds" (September 2017)

70. Christina Nelles: "Optimization and process adaptation of surface hygiene and preparation of a guide for implementation using the example of LSG Sky Chefs Düsseldorf GmbH" (July 2017)

69. Gero Biesemann: "Finding a suitable rapid method for the operational self-monitoring of cleaning and disinfection measures carried out in the production of the sushi manufacturer Natsu Foods GmbH & Co. KG" (June 2017).

68. Vanessa Amon: "Investigations of Alicyclobacillus spp. in fruit juice beverages using multiplex real-time PCR and microbiological methods" (March 2017).

67th Annalena Rupp: "Inactivation of fungal spores and bacteria in food by microwave treatment and ebeam sterilization" (February 2017).

66th Ramona Breuer: "Evaluation of the risk of spoilage of non-alcoholic beverages of Gerolsteiner Brunnen GmbH & Co. KG by the fruit juice spoilage agent Alicyclobacillus acidoterrestris" (November 2016).

65. Ekatharina Schlothauer: "Effect of ozonated water on the microbiological-hygienic status of vegetables and fruits in the washing process" (July 2016)

64. Juliane Rabe: "Minimal inhibitory concentrations of eugenol, oregano oil and cinnamaldehyde in selected molds" (April 2016).

63. Sören Vreuls: "Methods and material validation according to DIN ISO 11133:2015-01 at the FSK Institute for Food Safety and Hygiene, Herzogenrath" (February 2016).

62. Sabine Paal: "Development of an olive-flavored ice cream and a HACCP concept for the manufacturing process" (August 2015)

61. Claudia Schaal: "Structured knowledge management with regard to demographic change" (August 2015)

60. Bettina Burkhardt: "Killing or inactivation of molds in the matrix bread using microwave pasteurization" (October 2014).

59. Alexandra Fegers: "Air hygiene in food production: theoretical foundation courses using meat processing as an example" (August 2014)

58. Julia Maria Schieck: "Transport evidence of Saccharomyces cerevisiae through the pathways of Vitis vinifera subsp. vinifera" (June 2014)

57. Anna Laugel: "Studies on the effect of ozonated water on Listeria monocytogenes using salmon as an example" (May 2014).

56. Inga Schlösser: "Antimicrobial effect of copper and silver ions on selected human pathogenic and spoilage microorganisms" (November 2013).

55. Sandra Schoemackers: "Microbiological-hygienic investigation of dried mushrooms and division of a proposal for guideline and warning values for evaluation" (September 2013)

54. Michaela Müller: "Risk assessment of allergenic substances basedand on the Vital 2.0 concept." (September 2013)

53. Mareen Schlunke: "Microbiological environmental monitoring (Biocontrol program) in pharmaceutical storage systems of the company A&M Stabtest" (July 2013).

52. Pia Deckner: "Validation of an allergen management for bulk goods using the example of the employee restaurants of Bayer Gastronomie GmbH" (July 2013)

51. Anna Jansen: "Creation and implementation of a food defense concept according to IFS6 in a beverage producing company" (June 2013)

50th Simon Lenz: "Investigation of washing water additives and their germ-reducing effects in minimally processed vegetable products" (November 2011)

49th Anna Janßen: "Comparison of active and conventional packaging under microbiological and sensory aspects using the example of pineapple and Intense tomatoes" (October 2011)

48. Inga Schlösser: "Investigations of growth conditions of xerophilic molds and osmotolerant yeasts as spoilage agents in marzipan" (September 2011)

47. Miriam Sari: "Identification of Bissochlamys fulva in apple samples and optimization of pasteurization to inactivate fungal growth" (September 2011).

46. Jasmin Blume: "Comparative study for rapid identification of Salmonella ssp. in spreadable raw sausage" (August 2011).

45. Mareen Schlunke: "Comparison of different test methods for the detection of Enterobacteriaceae in dairy products and minced meat" (July 2011)

44. Bettina Klar: "Current hygiene requirements for small medium-sized meat processing companies" (July 2011)

43. Benjamin Frömbgen: "Influence of wood chips on nutrient-competitive displacement of Brettanomyces yeasts by Sacharromyces cerevisiae" (March 2011).

42. Andrea Weller: "Development of a hygiene concept for a mass catering operation" (December 2010)

41. Lisa Frenzel: "Investigations on the efficacy of antimicrobially active films on cheese cut surfaces with selected test germs" (October 2010)

40. Kathrin Künzel: "Microbiological-hygienic comparison of two dipping methods or agents with the aim of optimizing the hygienic quality of cut lettuce" (September 2010)

39. Annika Jannike: "Determination of the requirements for a scale-up capable pilot plant based on an ACTUAL analysis of tofu production" (September 2010)

38. Anna Katharina Kops: "Influence of ionizing radiation on food ingredients during preservation" (September 2010)

37. Amelie Gerdemann: "Development of a risk analysis for cold chain interruption in relation to picking and logistics services in airline catering using the example of LSG Sky Chefs" (August 2010)

36. Ulrike Zanzen: "Cadmium in cocoa: occurrence, significance and toxicity" (August 2010)

35. Simone Rong: "The properties of probiotics and their effect on intestinal flora using the example of Lactobacillus spp." (August 2010)

34. Heiko Leonards: "Creation of a quality assurance concept of a stadium outdoor gastronomy using the example of the BayArena in Leverkusen" (August 2010)

33. Anne Böing: "Creation and introduction to a basic hygiene concept taking into account personnel and environmental hygiene using the example of a medium-sized food company" (August 2010)

32. Ramona Ivonne Kleinhaus: "Preparation of checklists for the induction of laboratory staff at the BAV Institute" (August 2010)

31. Caroline Fritsch: "Enzymatic induced changes in strawberries and their dependence on pasteurization temperature" (July 2010)

30. Janine Magath: "Investigations on the validity of cultural alternative methods for the detection of Salmonella in food considering the applicability in a service laboratory" (January 2010)

29. Christine Müller / Carola Musmann (Cooperative thesis): "Microbial and hygienic status of Thai food in mobile kitchens and students' canteen at Chulalongkorn University, Bangkok" (August 2009).

28. Kristina Künkel: "Evaluation of microbiological risks (pathogens) in raw materials of FRoSTA AG at the Schottke plant" (August 2009)

27. Claudia Ley: "Elaboration of the integration possibility of a fructose production into the existing liquid sugar production of the Euskirchen plant" (August 2009)

26. Saskia Schimpe: "Implementation of a sensory incoming goods inspection in a meat processing plant with special regard to auxiliary materials" (August 2009)

25. Verena Schadick: "Compilation of a compendium in the field of dairy/milk" (July 2009)

24. Katharina Mumm: "Modern microbiological and molecular biological methods for the identification of yeasts and bacteria using the example of the yeast/bacterial isolate "GH140" in winemaking" (July 2009)

23 Tina Paulus: "Microbiological investigation and evaluation of wood use in winemaking with regard to wine off-flavors caused by Brettanomyces/Dekkera ("Brett aroma, horse sweat, monkey poop")" (February 2009)

22. Tessa K. Radtke: "Development of an innovative wellness drink based on fermented fruits" (February 2009)

21. Hanna Verleysdonk: "Creation of a hygienic design concept for gastronomic units of the stadium gastronomy after the reconstruction of the BayArena, Leverkusen" (August 2008)

20.Birte Mowe: "Microbiological and molecular biological detection of wine-relevant yeasts with special consideration of the microsatellite technique" (August 2008)

19.Julia Hamacher: "Revision of the food offer in a community catering operation with regard to food as well as allergen labeling" (August 2008)

18. Susanne Schwank: "Determination of the microbiological hazard potential when food temperatures fall below 65° in long-distance catering" (April 2008)

17.Dana Kässler: "Development of a concept for establishing, securing and continuously improving basic hygiene in the area of catering units at the Cologne Trade Fair" (April 2008)

16. Anne Steinberg: "Hygiene training in the food sector in accordance with current legal requirements" (April 2008)

15.Nadine Will: "Development of new cleaning strategies to optimize the hygiene status with special regard to economic efficiency, with subsequent implementation in a food company" (November 2007)

14.Simone Giesen: "Comparative Studies on the Detection of Bacteria in Beverages"

13. Helder C. Machado: "Microbiological-Hygienic Studies on the Cleaning Success of Different Cleaning Methods on a Household Steamer" (August 2007)

12.Julia Burkhardt: "Adaptation and optimization of an existing HACCP concept to the current process steps in a Cook & Chill operation" (August 2007)

11.Regina Nattmann: "Validation of two application procedures for microbiological drinking water analysis" (July 2007)

10. Cornelia Richter: "HACCP concept in the private brewery Bolten GmbH & Co. KG: elaboration with special consideration of the new barrel and bottle filling" (June 2007)

9.Heidrun Koch: "Establishment and set-up of a food analysis and microbiology laboratory in a meat processing plant" (February 2007)

8.Annika Meier: "Investigations on the integration of flow cytometry in the microbiological standard analysis of Zentis GmbH & Co. KG" (February 2007)

7. Mareike Brosche: "Microbiological rapid methods in food microbiology and hygiene" (February 2007)

6.Kathrin Höppler: "Validation of temperature reduction in cold storage as a function of microbial multiplication in the product" (February 2007)

5.Selamauit Ghirmai: "Microbiological-air-hygienic investigations in a medium-sized food company with special regard to the detection of mycotoxin-forming molds" (December 2006)

4. Anja Gorres: "Development of a hygiene training concept especially for bakeries and butcheries" (November 2006)

3.Sonja Huber: "Validation of flow cytometry for the determination of bacterial counts in ground meat products" (August 2006)

2.Annika Hagen: "Validation for the detection of Staphylococcus aureus: use of different plating methods and egg yolk supplements" (June 2006)

1. Anne Krabiell: "Studies on the microbial flora in honeys" (June 2006).